Interferon in Replicon Cells Enhances the Antiviral Activity of Alpha Suppresses Polyprotein Maturation and of Hepatitis C Virus NS3 Protease, SCH 503034, a Mechanism-Based Inhibitor
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چکیده
10.1128/AAC.50.3.1013-1020.2006. 2006, 50(3):1013. DOI: Antimicrob. Agents Chemother. Girijavallabhan and F. G. Njoroge A. Skelton, X. Tong, S. Venkatraman, E. Xia, V. Ingravallo, C. Jiang, R. Kong, J. Lu, J. Pichardo, A. Prongay, Butkiewicz, R. Chase, F. Gheyas, A. Hart, D. Hesk, P. B. A. Malcolm, R. Liu, F. Lahser, S. Agrawal, B. Belanger, N. Interferon in Replicon Cells Enhances the Antiviral Activity of Alpha Suppresses Polyprotein Maturation and of Hepatitis C Virus NS3 Protease, SCH 503034, a Mechanism-Based Inhibitor
منابع مشابه
Preclinical characterization of the antiviral activity of SCH 900518 (narlaprevir), a novel mechanism-based inhibitor of hepatitis C virus NS3 protease.
Small-molecule hepatitis C virus (HCV) NS3 protease inhibitors such as boceprevir (SCH 503034) have been shown to have antiviral activity when they are used as monotherapy and in combination with pegylated alpha interferon and ribavirin in clinical trials. Improvements in inhibitor potency and pharmacokinetic properties offer opportunities to increase drug exposure and to further increase the s...
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Background: Hepatitis C is a global health problem. The exact mechanisms by which hepatitis C virus (HCV) can evade the host immune system have become controversial. Whether HCV polyproteins modulate IFN signalling pathways or HCV proteins are responsible for such a property is the subject of interest. Therefore, an efficient baculovirus delivery system was developed to introduce the whole geno...
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HCV-796 is a nonnucleoside inhibitor of the hepatitis C virus (HCV) nonstructural protein 5B (NS5B) polymerase, and boceprevir is an inhibitor of the NS3 serine protease. The emergence of replicon variants resistant to the combination of HCV-796 and boceprevir was evaluated. Combining the inhibitors greatly reduced the frequency with which resistant colonies arose; however, some resistant repli...
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